You can complete the game within one playthrough, given that you give yourself a handicap right off the bat and take note of some of the missables. Although you would start with the handicap by equipping a weaker melee weapon, this is pretty much alleviated by focusing toward a ranged build. You would get the opportunity to play with the other weapons during the post-game, as the achievement is only required for the base game. The game has a lot of collectibles, but you can clean them up in the post-game, especially since the game gives you a lot of tools after you finish the base game. You could realistically finish without a guide or go through the base game without worrying about most of the collectible achievements.
Estimated Time: 16-20 hours
The game is pretty short but fun and challenging, and attempting to complete it also brings in interesting post-game content. The game is designed in such a way that it’s meant to be completed.